Loxapine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRA2AADRB2HTR2BADRA2CADRA2BSLC6A4MU-TYPESLC6A2HTR2CKAPPA-TYPECHRM2HRH1CHRM5ADRA1BADRA1DCHRM3HRH2HTR7HTR6DRD4MUSCARINICHTR5ADRD5HTR3ADELTA-TYPENPR2HRH4KCNT1
36 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)25 targets overlapping
Amine ligand-binding receptors25 targets overlapping
G alpha (q) signalling events10 targets overlapping
Uncovered Pathway Targets
202 totalADORA2BADORA3ADRB1ADRB3AGTR1AGTR2APLNRAPPAVPR1AAVPR1B+192 more…
Genes present in the top pathway union that Loxapine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,052.97#1 gap-filler · 29 targets covered · evidence score 44.3
ADRB1ADRB3TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16TAS2R19TAS2R20+17
Fluspirilene
score 3,877.918#2 gap-filler · 15 targets covered · evidence score 49.7
ADORA3GHSRHCRTR1HTR1EMC3RMLNRNPSR1NTSR1OPRD1OPRL1OPRM1TAAR1+3
578 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.