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BiohacksAI

Evidence-Based Biohacking

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BiohacksAI/Mechanism Hypothesis/Lumefantrine

Lumefantrine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2ESR1CYP1A2THRBCYP3A4SYKTYROSINE-PROTEINNSD2RORCHISTONE-LYSINEKCNH2RARAHOMOAHRJUNATXN2CASP3CASP7

21 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations6 targets overlapping
Phase I - Functionalization of compounds6 targets overlapping
Cytochrome P450 - arranged by substrate type6 targets overlapping

Uncovered Pathway Targets

82 total
AADACAHCYALDH1A1ALDH2AOC1ARNTCBR3CES1CES2CYP11B1+72 more…

Genes present in the top pathway union that Lumefantrine does not directly modulate.

Top Stack Candidates

Quercetin

#1 gap-filler · 14 targets covered · evidence score 43.4

score 2,860.909
CYP19A1CYP1A1CYP1B1CYP2C8HSP90AB1MAOANNMTRXRAABCB1ABCC1ABCG2PON1+2
Ritonavir

#2 gap-filler · 10 targets covered · evidence score 53.4

score 2,761.057
CYP2B6CYP3A43CYP3A5CYP3A7CYP3A7-CYP3A51PUGT1A1ABCB1SLCO1B1SLCO1B3SLCO2B1

568 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.