Luteolin 5,7,3',4'-tetrahydroxy-flavone, — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2C9CYTOCHROMECYP1A2CYP3A4NFE2L2SYKTYROSINE-PROTEINCHAINNSD2RORCMUSHISTONE-LYSINEEUCHROMATICDRD3CYP19A1PPARGNTMT1SLC6A3CFTRMAPTALDEHYDECA1IFNB1POLKCA2CA7CA12CA4HDAC6BAZ2BMAOAPOLBNFKB1ALOX12APPPOLIALOX15HPGDRAPGEF3MCL1ABCG2FEN1POLHRELABLMCYP1B1GSK3BAURKBSMN2TTRAKR1B10CDK1SLCO2B1PARP1TNFRSF10BCLK1CSNK2A1CYP1A1GSK3AALOX15BAMINEGPR35ADORA1AKR1B1FLT3ALOX5PIP4K2APIM1DYRK1APSIP1CDK5CSNK2A2PSMB5XDHYES1GSTO1DPP4MAPK10NFKB2TFE3TRAUSP17L5BACE1CSNK2BPIM2STK16ALPIGAATOP1USP28USP30CDK5R1CSNK2A3CCNB1CCNB2CCNB3FXNMACROPHAGEWRNCLK3IP6K2MKNK2TYRRPS6KA3PAFAH1B3HTRA1MATRIXOTUD3USP8CYBBNOX4IPMKINTERSTITIALMKNK1NR1H3PAFAH1B2USP10AKT1CASEINGLO1NR1H2SIRT6UCHL1USP7ADAMTS4METTL3SETD7TNKSTNKS2ARG1CBR3METTL14CD38MONOCARBOXYLATEPBRM1
136 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Interleukins16 targets overlapping
Deubiquitination14 targets overlapping
Intracellular signaling by second messengers13 targets overlapping
Uncovered Pathway Targets
289 totalADRM1ANXA2BCL2L1BIRC5CASP1CCL2CDC42CFL1CHUKCREB1+279 more…
Genes present in the top pathway union that Luteolin 5,7,3',4'-tetrahydroxy-flavone, does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,888.899#1 gap-filler · 46 targets covered · evidence score 44.2
ADRM1CREB1CTSGHIF1AIFNGPSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7+34
Crizotinib
score 11,600.742#2 gap-filler · 39 targets covered · evidence score 46.7
CSF1RFYNIFNGIKBKBINPPL1IRAK1IRAK3JAK3LCKLYNMAP2K3MAP3K3+27
736 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.