Maprotiline — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6ARCYP2C9CYTOCHROMETDP1THRBCYP3A4CYP3A7SYKTYROSINE-PROTEINGLI3NSD2RORCHISTONE-LYSINETP53KCNH2RARACHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2AESR2DRD1ADRA2APPARGADRB2HTR2BTSHRADRA2CJUNADRA2BATXN2SLC6A3PMP22SLC6A2HTR2CMAPTSODIUM-DEPENDENTHRH1ALPHA-2ACHRM5CHRM4CASP3CHRM3ALPHA-2BALPHA-1DALPHA-1AALPHA-2CCASP7ALPHA-1BMUSCARINICMTORHISTAMINEDRD5THYROIDCACNA1BTOR1AKCNJ5KCNJ6
60 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)17 targets overlapping
Amine ligand-binding receptors16 targets overlapping
G alpha (q) signalling events8 targets overlapping
Uncovered Pathway Targets
355 totalADORA2BADORA3ADRA1BADRA1DADRB1ADRB3AGTR1AGTR2APLNRAPP+345 more…
Genes present in the top pathway union that Maprotiline does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,167.819#1 gap-filler · 40 targets covered · evidence score 44.2
CREB1F12HDAC1HDAC2IFNB1PLATADRM1ESR1HDAC3PSMA1PSMA2PSMA3+28
Sorafenib
score 9,626.827#2 gap-filler · 38 targets covered · evidence score 44.4
ADORA3HTR6HTR7MLNRMAPK1MAPK3RPS6KA1ABL1CDK5CSKFGRFYN+26
832 more candidates · full stack optimisation locked
Enter your API token to unlock the complete analysis.
BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.