BiohacksAI/Mechanism Hypothesis/Melphalan

Melphalan — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINNSD2RORCHISTONE-LYSINENUCLEARTP53ABCB1KCNH2RARAEUCHROMATICHOMOPTGS1ATXN2ATAD5PMP22NR1H4STK33MDM2MDM4CASP3BRCA1CASP7BARD1PLGPLAUPLAUR

41 known targets mapped from PubChem bioassay data

Pathway Context

SUMOylation8 targets overlapping

SUMO E3 ligases SUMOylate target proteins8 targets overlapping

Biological oxidations7 targets overlapping

Uncovered Pathway Targets

98 total

AURKAAURKBBIRC5BLMCREBBPCTBP1DNMT1DNMT3BEIF2AK2EP300+88 more…

Genes present in the top pathway union that Melphalan does not directly modulate.

Top Stack Candidates

Quercetin

#1 gap-filler · 18 targets covered · evidence score 43.4

score 3,370.454

AURKBBLMNFKB2NR3C1PGRPPARGRELARXRATOP1TOP2AAHRCYP19A1+6

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 16 targets covered · evidence score 40.6

score 3,295.858

AURKBBLMNFKB2NR1H2NR1H3PARP1PPARGRELATOP1WRNCBR3CYP19A1+4

541 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.