Metergoline — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6CYTOCHROMETDP1THRBCYP3A7SYKTYROSINE-PROTEINCHAINGLI3RORCKCNH2EUCHROMATICCHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRA2AHTR2BADRA2CADRA2BSLC6A3ACHESLC6A4MU-TYPESLC6A2HTR2CGMNNSODIUM-DEPENDENTSTK33CHRM2HRH1ALPHA-2AABCB11ADRA1BADRA1DCHRM3ALPHA-2BHRH2HTR7HTR6ALPHA-1DOPRD1ALPHA-1AALPHA-2CDRD4BAZ2BALPHA-1BHTR1BMUSCARINICOPRK1HTR1DCBX1GPR32HTR5AHISTAMINEMCL1THPOMAP4K2HTR1FPLA2G7HTR1EPRMT1NPY2RHRH3CACNA1HBCL2L1HTR4HRH4SUBSTANCE-KCIB1MPIPREPLPTGER3PTGER4ACETYLCHOLINESTERASEHPSE
80 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)29 targets overlapping
Amine ligand-binding receptors25 targets overlapping
G alpha (i) signalling events11 targets overlapping
Uncovered Pathway Targets
198 totalADORA2BADORA3ADRB1ADRB2ADRB3AGTR1AGTR2APLNRAPPAVPR1A+188 more…
Genes present in the top pathway union that Metergoline does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,200.645#1 gap-filler · 30 targets covered · evidence score 44.3
ADRB1ADRB2ADRB3TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16TAS2R19+18
Fluspirilene
score 3,599.803#2 gap-filler · 14 targets covered · evidence score 49.7
ADORA3ADRB2GHSRHCRTR1MC3RMLNRNPSR1NTSR1OPRL1OPRM1TAAR1GNA15+2
584 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.