Methimazole — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C9NFE2L2RATTUSEUCHROMATICESR2PTGS1JUNHSPB1GPR32ANO1LACTOPEROXIDASE
11 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Nuclear Receptors3 targets overlapping
ESR-mediated signaling3 targets overlapping
Intracellular signaling by second messengers2 targets overlapping
Uncovered Pathway Targets
171 totalAGO2AKR1C3AKT3ALDH1A1CARM1CBFBCDK9CREB1CREBBPDLD+161 more…
Genes present in the top pathway union that Methimazole does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,882.098#1 gap-filler · 41 targets covered · evidence score 44.2
CREB1ESR1HDAC1HDAC3PGRPPARDRARAADRM1HDAC2PSMA1PSMA2PSMA3+29
sp600125
score 5,711.884#2 gap-filler · 23 targets covered · evidence score 43.3
ERBB4MAPK1PDPK1CAMK2BCAMK2DCAMKK2CSNK2A1FGFR1FGFR3FLT3FRKGSK3A+11
588 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.