BiohacksAI/Mechanism Hypothesis/Methylene Blue

Methylene Blue — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1TDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINGLI3NSD2RORCHISTONE-LYSINENUCLEARTP53RARADRD3CYP19A1AHRPPARGTSHRJUNNTMT1ATXN2ATAD5ACHECFTRNR1H4SMAD3MAPTMDM2MDM4IFNB1IDH1MITFCASP3HDAC9TOP1P1BAZ2BMAOAGFERPOLBRGS4PTGER2APPNR5A1MCL1FEN1NR5A2IP6K1SENP8BLMNPSR1RXFP1APAF1NCOA3UHRF1TNFRSF10BMBD2TRPC6PTPN1HCRTR1JAK2TRPC4NCOA1PSIP1GSTO1RAD52ABHD4NCOA2GRK2MLLT3CASP6STAT1APLNRSIX1TNFSF10FOSBGSRNCF1ATMCASP9HKDC1CCT2LARGE1MSTN

93 known targets mapped from PubChem bioassay data

Pathway Context

SUMOylation14 targets overlapping

SUMO E3 ligases SUMOylate target proteins14 targets overlapping

Biological oxidations12 targets overlapping

Uncovered Pathway Targets

88 total

AURKAAURKBBIRC5BRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2EP300+78 more…

Genes present in the top pathway union that Methylene Blue does not directly modulate.

Top Stack Candidates

Quercetin

#1 gap-filler · 13 targets covered · evidence score 43.4

score 2,557.67

AURKBNFKB2NR3C1PGRRELARXRATOP1TOP2ACYP1A1CYP1B1CYP2C8HSP90AB1+1

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 11 targets covered · evidence score 40.6

score 2,454.16

AURKBNFKB2NR1H2NR1H3PARP1RELATOP1WRNCBR3CYP1A1CYP1B1

472 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.