BiohacksAI/Mechanism Hypothesis/Methylergonovine

Methylergonovine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6CYTOCHROMECYP3A7CHAINEUCHROMATICDRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AVDRHTR2BADRA2CADRA2BACHEHTR2CALDEHYDEHRH1ALPHA-2AADRB1NNMTPNMTALPHA-2BHRH2GAMTGNMTHNMTCATECHOLRGS4HTR1FHTR1ECIB1

34 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)14 targets overlapping

Amine ligand-binding receptors14 targets overlapping

G alpha (q) signalling events6 targets overlapping

Uncovered Pathway Targets

278 total

ADORA2BADORA3ADRA1BADRA1DADRA2AADRB2ADRB3AGTR1AGTR2APLNR+268 more…

Genes present in the top pathway union that Methylergonovine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 34 targets covered · evidence score 44.2

score 10,656.697

CREB1ADRM1PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3+22

Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on

#2 gap-filler · 33 targets covered · evidence score 44.3

score 9,787.303

ADRA1BADRA1DADRB2ADRB3DRD4TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14+21

725 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.