Mianserin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6ARTHRBCYP3A7PGRRATTUSCHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRA2AHTR2BADRA2CJUNADRA2BSLC6A4SLC6A2HTR2CKAPPA-TYPESODIUM-DEPENDENTCHRM2HRH1ALPHA-2ACHRM5ADRA1BADRA1DCHRM3ALPHA-2BHRH2HTR7HTR6ALPHA-1DALPHA-1AALPHA-2CDRD4ALPHA-1BHTR1BMUSCARINICHTR1DSCN2AHISTAMINESCN3ASCN1AHTR1FHTR3ACNR1SLC18A2HTR3BHTR4HEATTRANSPORTERHTR3CHTR3DHTR3E
58 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)24 targets overlapping
Amine ligand-binding receptors23 targets overlapping
G alpha (q) signalling events10 targets overlapping
Uncovered Pathway Targets
203 totalADORA2BADORA3ADRB1ADRB2ADRB3AGTR1AGTR2APLNRAPPAVPR1A+193 more…
Genes present in the top pathway union that Mianserin does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,200.645#1 gap-filler · 30 targets covered · evidence score 44.3
ADRB1ADRB2ADRB3TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16TAS2R19+18
Fluspirilene
score 4,043.593#2 gap-filler · 16 targets covered · evidence score 49.7
ADORA3ADRB2GHSRHCRTR1HTR1EMC3RMLNRNPSR1NTSR1OPRD1OPRL1OPRM1+4
591 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.