Niclosamide — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3PGRNSD2RORCMUSHISTONE-LYSINENUCLEARTP53ABCB1RARAEUCHROMATICDRD1CYP19A1AHRIFNGADRA2ATSHRATXN2ATAD5PMP22CFTRMAPTGMNNSTK33CHRM2RXRAMDM2IL1BMDM4IDH1HIF1AMITFHDAC9TOP1P1BRCA1BARD1MTORNR0B1THPONLRP3SENP8SMN2ANO1THYROIDTNFRSF10BHCRTR1PRKAA2NPR2SRCPKMPRKAA1RAB9ASENP6OXTRPRKAB1PRKAB2PRKAG1PRKAG2PRKAG3GLI1SENP7NPC1CRHR2NPR1PINK1ACP1CRHBPGCKGNASSTAT3KCNT1SMN1NPY4RNPY4R2FZD1
90 known targets mapped from PubChem bioassay data
Pathway Context
Transcriptional Regulation by TP5313 targets overlapping
Regulation of TP53 Activity13 targets overlapping
Regulation of T cell activation by CD28 family12 targets overlapping
Uncovered Pathway Targets
174 totalAGO2AKT3ATMAURKAAURKBBIRC5BLMCARM1CASP1CASP2+164 more…
Genes present in the top pathway union that Niclosamide does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,016.86#1 gap-filler · 40 targets covered · evidence score 44.2
HDAC1HDAC2ADRM1EPAS1NFKB1NFKB2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6+28
Quercetin
score 7,105.578#2 gap-filler · 30 targets covered · evidence score 43.4
AURKBBLMCDK1CSNK2A1CSNK2A2CSNK2BMAPK14NUAK1USP7YWHABEZH2GSK3B+18
377 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.