BiohacksAI/Mechanism Hypothesis/Nisoldipine

Nisoldipine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINGLI3PGRRATTUSNSD2RORCHISTONE-LYSINENUCLEARTP53NR3C1ABCB1KCNH2RARAEUCHROMATICDRD3HOMODRD2ESR2CYP19A1AHRADRB2VDRJUNPMP22CFTRMU-TYPESMAD3GMNNMDM2IL1BMDM4SMAD2ABCB11IDH1HIF1ACREB1ADORA3HSPB1KCNMB1KCNMB2CBX1CACNA1CADENOSINEKCNMB4CGMP-INHIBITEDKCNMA1TARDBPSCN5AKCNQ1PRMT1KCNJ2MRGPRX1CGASPLK1KCNQ2LRRC26MLLT3HNF4APLIN5CACNA1DCACNA1FCACNA1S

78 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway10 targets overlapping

Deubiquitination10 targets overlapping

SUMOylation9 targets overlapping

Uncovered Pathway Targets

133 total

ESRRBESRRGHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2NR1H3+123 more…

Genes present in the top pathway union that Nisoldipine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 40 targets covered · evidence score 44.2

score 12,061.124

PPARDADRM1NLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+28

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 23 targets covered · evidence score 40.6

score 5,168.331

NR1H2NR1H3PPARGCDK1OTUD3POLBPSMB5TNKSTNKS2UCHL1USP10USP17L5+11

365 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.