BiohacksAI/Mechanism Hypothesis/Noscapine

Noscapine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2CYTOCHROMECYP3A4CYP3A7TP53PTGS2ADRB1TOP1P1PTGER2SENP8SLC22A2GHSRAGTR1NPR2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TUBB8B

33 known targets mapped from PubChem bioassay data

Pathway Context

Cell Cycle17 targets overlapping

Cell Cycle, Mitotic17 targets overlapping

Mitotic G2-G2/M phases17 targets overlapping

Uncovered Pathway Targets

227 total

ABL1ADRM1AKT3ATMAURKAAURKBBARD1BIRC5BLMBRCA1+217 more…

Genes present in the top pathway union that Noscapine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 40 targets covered · evidence score 44.2

score 12,113.256

ADRM1HDAC1HDAC8NSD2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+28

Sorafenib

#2 gap-filler · 30 targets covered · evidence score 44.4

score 7,221.736

ABL1AURKAAURKBCDK1CDK6CDK7CSNK1A1GMNNGSK3BLYNMAPK1MAPK11+18

572 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.