o-Phthalaldehyde — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARCYP2C9NR1I2ESR1TDP1CYP1A2THRBESRRANFE2L2CHAINGLI3RORCNUCLEARTP53NR3C1RARACHRM1ESR2CYP19A1PPARGADRB2VDRTSHRATAD5SMAD3SMAD2POLKCREB1CASP3CASP7USP1
31 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway9 targets overlapping
SUMOylation8 targets overlapping
SUMO E3 ligases SUMOylate target proteins8 targets overlapping
Uncovered Pathway Targets
138 totalESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+128 more…
Genes present in the top pathway union that o-Phthalaldehyde does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,345.42#1 gap-filler · 42 targets covered · evidence score 44.2
PGRPPARDHDAC1HDAC2MITFNFKB2PARP1RELAADRM1HIF1ANLRP3PSMA1+30
Luteolin 5,7,3',4'-tetrahydroxy-flavone,
score 5,177.636#2 gap-filler · 23 targets covered · evidence score 40.6
NR1H2NR1H3AURKBBLMNFKB2PARP1RELATOP1WRNCDK1CFTROTUD3+11
461 more candidates · full stack optimisation locked
Enter your API token to unlock the complete analysis.
BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.