BiohacksAI/Mechanism Hypothesis/Oleanolic Acid

Oleanolic Acid — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

TDP1NFE2L2TYROSINE-PROTEINRATTUSMUSIFNGPOLBGPBAR1MAP4K2RELAGSK3BAKR1B10PTPN1PRKAA2PRKAA1PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3CDC25BPLA2G1BG-PROTEINDUSP3PTPN2CES1PTPRCF3PCNAFUN14

30 known targets mapped from PubChem bioassay data

Pathway Context

Regulation of T cell activation by CD28 family10 targets overlapping

Co-inhibition by PD-110 targets overlapping

Regulation of PD-L1(CD274) expression10 targets overlapping

Uncovered Pathway Targets

150 total

ADRM1AGO2AKT3ASH2LBRD4CDC42CDK4COPS5CREBBPCSK+140 more…

Genes present in the top pathway union that Oleanolic Acid does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 39 targets covered · evidence score 44.2

score 11,774.436

ADRM1EPAS1HIF1ANFKB1NFKB2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7+27

Quercetin

#2 gap-filler · 21 targets covered · evidence score 43.4

score 4,937.163

CSNK2A1CSNK2A2CSNK2BEZH2HIF1ANEK2NFKB1NFKB2PIK3CGPIK3R1PSMB5SRC+9

359 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.