BiohacksAI/Mechanism Hypothesis/Ouabain

Ouabain — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARESR1TDP1ESRRANFE2L2SYKTYROSINE-PROTEINCHAINNSD2HISTONE-LYSINENUCLEARNR3C1KCNH2CYP19A1TSHRATXN2ATAD5SLC6A3GMNNSTK33MDM2MDM4IFNB1YAP1HLA-BGPR151APPGPR32NPY1RNPY2RPTBP1NOD1KLF5SLCO4C1NOD2GPR119ATP1A1ATP1B1TNFSF10ATP1A2ATP1A4TNFATP1A3ATP1B2ATP1B3FXYD2S1PR4

47 known targets mapped from PubChem bioassay data

Pathway Context

SARS-CoV Infections15 targets overlapping

Potential therapeutics for SARS11 targets overlapping

Muscle contraction9 targets overlapping

Uncovered Pathway Targets

153 total

AKT3BCL2L1BRD4BTKCASP1CHUKCHURC1-FNTBCREBBPCSNK1A1CTSL+143 more…

Genes present in the top pathway union that Ouabain does not directly modulate.

Top Stack Candidates

Crizotinib

#1 gap-filler · 14 targets covered · evidence score 46.7

score 4,124.203

BTKIKBKBIKBKEIRAK1JAK3MAP3K7NPM1RIPK2ROCK2SRPK1TBK1TYK2+2

sp600125

#2 gap-filler · 14 targets covered · evidence score 43.3

score 3,788.791

CSNK1A1GSK3AGSK3BIKBKBJAK3PDPK1ROCK2TYK2CAMK2BCAMK2DHIPK2MYLK+2

369 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.