Pemetrexed — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
SYKTYROSINE-PROTEINCHAINNSD2HISTONE-LYSINETYMSDHFRFOLATEFOLR1SLC19A1SLC46A1ATICFPGSGARTTHYMIDYLATE
15 known targets mapped from PubChem bioassay data
Pathway Context
Metabolism of vitamins and cofactors4 targets overlapping
Metabolism of water-soluble vitamins and cofactors4 targets overlapping
Metabolism of folate and pterines4 targets overlapping
Uncovered Pathway Targets
189 totalAASDHPPTABCC1AKR1B10AKR1C1AKR1C3AKR1C4AOX1CD38COQ8ACOQ8B+179 more…
Genes present in the top pathway union that Pemetrexed does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,918.167#1 gap-filler · 38 targets covered · evidence score 44.2
CTRB1PRSS1PRSS3ADRM1HDAC1HDAC8PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6+26
Quercetin
score 5,663.535#2 gap-filler · 25 targets covered · evidence score 43.4
ABCC1AKR1B10HSP90AA1NNMTPNLIPABL1AURKBBLMCDK1CSNK2A1CSNK2A2CSNK2B+13
389 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.