BiohacksAI/Mechanism Hypothesis/Pergolide

Pergolide — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYTOCHROMECYP3A4KCNH2DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRA2AHTR2BADRA2CADRA2BHTR2CHRH1ALPHA-2AADRA1BADRA1DALPHA-2BHRH2HTR7HTR6ALPHA-1DALPHA-1AALPHA-2CDRD4ALPHA-1BHTR1BHTR1DHTR5ASNCAHTR1FDRD5HTR3AHTR3BHTR4HTR5B

38 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)20 targets overlapping

Amine ligand-binding receptors20 targets overlapping

G alpha (q) signalling events7 targets overlapping

Uncovered Pathway Targets

180 total

ADORA2BADORA3ADRB1ADRB2ADRB3AGTR1AGTR2APLNRAPPAVPR1A+170 more…

Genes present in the top pathway union that Pergolide does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 17 targets covered · evidence score 48.7

score 4,087.86

ADRB2APLNRAVPR1ACHRM1CHRM2CHRM3GALR2GHSRHRH4MLNROXTRSSTR5+5

Fluspirilene

#2 gap-filler · 16 targets covered · evidence score 49.7

score 3,988.992

ADORA3ADRB2CHRM3GHSRHCRTR1HTR1EMC3RMLNRNPSR1NTSR1OPRD1OPRL1+4

631 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.