Perphenazine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARNR1I2CYTOCHROMETDP1CYP1A2THRBESRRACYP3A7SYKTYROSINE-PROTEINCHAINGLI3RATTUSNSD2RORCHISTONE-LYSINETP53ABCB1KCNH2RARACHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AIFNGADRA2AADRB2HTR2BTSHRADRA2CADRA2BATXN2SLC6A3SLC6A4SMAD3HTR2CKAPPA-TYPEGMNNHRH1SMAD2CHRM5CHRM4CASP3HTR7HTR6CASP7KCNMB1KCNMB2GFERRAPGEF4CBX1MTORTHPOMPHOSPH8MAP4K2KCNMB4PLA2G7KCNMA1APAF1KCNJ2GLP1RGPR35RAC-ALPHANPR2RAD52MLLT3VOLTAGE-GATEDUBE2NPREPLTOR1AAPLNRGPR119FPR1AOX1GPR183DHCR24GPR65FPR3ALDH1A1EBPCX3CR1
87 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)26 targets overlapping
Amine ligand-binding receptors18 targets overlapping
Hemostasis11 targets overlapping
Uncovered Pathway Targets
297 totalADORA2BADORA3ADRA1BADRA1DADRB1ADRB3AGTR1AGTR2APPAVPR1A+287 more…
Genes present in the top pathway union that Perphenazine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,447.039#1 gap-filler · 31 targets covered · evidence score 44.3
ADRA1BADRA1DADRB1ADRB3DRD4CREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16+19
Sorafenib
score 5,251.01#2 gap-filler · 21 targets covered · evidence score 44.4
ADORA3MLNRABL1CDK5CSKFGRFYNIFNB1LCKLYNMAPK1MAPK14+9
670 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.