Picrotoxin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
GABRA2GABRA3GABRA4GABRB2GABRB3GABRG2GABRA5GABRA6GABRB1GABRDGABREGABRG1GABRG3GABRPGLRA1GAMMA-AMINOBUTYRICGABRQGLRA2GABRR1GABRR2GABRR3GLRA3GLRB
23 known targets mapped from PubChem bioassay data
Pathway Context
Neuronal System18 targets overlapping
Transmission across Chemical Synapses18 targets overlapping
Neurotransmitter receptors and postsynaptic signal transmission18 targets overlapping
Uncovered Pathway Targets
246 totalABATABCC8ABCC9ACHEADCY9ALDH2ALDH5A1BCHECACNA1BCACNA2D1+236 more…
Genes present in the top pathway union that Picrotoxin does not directly modulate.
Top Stack Candidates
Sorafenib
score 10,774.624#1 gap-filler · 41 targets covered · evidence score 44.4
CAMK2BMAOAMAPK1MAPK3NTRK3RPS6KA1RPS6KA6SLC6A3SRCAXLBRAFCDK5+29
Crizotinib
score 9,438.713#2 gap-filler · 34 targets covered · evidence score 46.7
CAMKK2CASKKCNH2NTRK3PRKAA1SLC6A3SLC6A4SRCALKAXLFERFES+22
723 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.