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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/pictilisib

pictilisib — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

TDP1SYKTYROSINE-PROTEINNSD2MUSHISTONE-LYSINEABCB1MITFHDAC9NNMTPNMTGAMTGNMTHNMTCATECHOLHDAC6MTORCLK1FLT3PHOSPHATIDYLINOSITOLRAC-ALPHAHDAC10CSNK2A2HDAC11HDAC4HDAC5HDAC7YES1MAPK10TFE3HDAC1HDAC2HDAC3HDAC8STK16PIK3CGPLK4PIK3R1PIK3CDMAPK9CSNK1EDYRK2RPS6KA3PIK3CBGAKMAPK8CLK2CLK4TPTEP2-CSNK1ENQO2PIK3CAEPHB6HIPK4TYK2NTRK1MELKDNA-DEPENDENTDYRK1BPIK3R5CSNK1DAAK1CDK16MAP3K19TTKHIPK2DAPK1PIK3R2RPS6KA6LRRK2CDK7DAPK3PIK3C2BPIK3C3IRAK3CDK18CAMK1CAMK1GHIPK1HIPK3PIK3C2ACILK1MYLK4PIK3C2GRIOK2

84 known targets mapped from PubChem bioassay data

Pathway Context

Intracellular signaling by second messengers14 targets overlapping
PIP3 activates AKT signaling14 targets overlapping
Signaling by Interleukins12 targets overlapping

Uncovered Pathway Targets

287 total
ADCY9ADRM1AGO2AKT3BADCAMK2BCAMK2DCAMKK1CAMKK2CASP9+277 more…

Genes present in the top pathway union that pictilisib does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 49 targets covered · evidence score 44.2

score 13,804.76
ADRM1CREB1ESR1ESR2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+37
Sorafenib

#2 gap-filler · 48 targets covered · evidence score 44.4

score 12,614.76
CAMK2BEZH2FGFR1FGFR2FGFR3FRKFYNGSK3BINSRIRAK1KITLCK+36

755 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.