BiohacksAI/Mechanism Hypothesis/Pioglitazone

Pioglitazone — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

RATTUSMUSHOMOADRA2APPARGNTMT1ABCB11ABCC2TBXA2RGAPDHMAOBPPARACARBONICYES1CISD1CHRNA10CACNA1FDLDPTK2BTRPM3PSMD1PEROXISOMEACADLATP5F1AATP5F1BCISD2CKBCLCF1CLCN6DCTN1DSTGOT2HPXIL12BIPO7KALRNLDHBMAKMPDZNF1OGDHPGK1PXKROR1SLC5A6SOX5SSX2IPSYNGAP1TAAR7BXK

50 known targets mapped from PubChem bioassay data

Pathway Context

Signaling by Interleukins3 targets overlapping

Hemostasis3 targets overlapping

Disorders of transmembrane transporters3 targets overlapping

Uncovered Pathway Targets

407 total

ADRM1ALOX15ALOX5ANXA2APPBCL2L1BIRC5CA1CASP1CCL2+397 more…

Genes present in the top pathway union that Pioglitazone does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 47 targets covered · evidence score 44.2

score 13,377.418

ADRM1CA1CREB1CTSGHIF1AIFNGNFKB1NFKB2PSMA1PSMA2PSMA3PSMA4+35

Sorafenib

#2 gap-filler · 38 targets covered · evidence score 44.4

score 8,898.784

CSF1RFYNHCKIFNGIRAK1JAK3LCKLYNMAOAMAP2K1MAP3K7MAPK1+26

957 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.