BiohacksAI/Mechanism Hypothesis/plumbagin [Supplementary Concept]

plumbagin [Supplementary Concept] — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

TDP1CYP1A2CHAINRORCMUSTP53VDRMAPTALDEHYDESTK33POLKMAOAPTGER2HPGDUSP1GAPDHTRPA1MAPK1RELACYP1B1EPIDERMALCYP1A1RAC-ALPHAHSPD1HSPE1CDC25BMAPK3FOCALTSTRECEPTOREP300KAT2BCDC25AXPO1

34 known targets mapped from PubChem bioassay data

Pathway Context

Cell Cycle7 targets overlapping

Cell Cycle, Mitotic7 targets overlapping

Signaling by Interleukins5 targets overlapping

Uncovered Pathway Targets

289 total

ABL1ADRM1AKT3ATMAURKAAURKBBARD1BIRC5BLMBRCA1+279 more…

Genes present in the top pathway union that plumbagin [Supplementary Concept] does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 51 targets covered · evidence score 44.2

score 13,717.416

ADRM1HDAC1HDAC8NSD2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+39

Crizotinib

#2 gap-filler · 34 targets covered · evidence score 46.7

score 9,610.849

ABL1AURKAAURKBCDK11ACDK11BEML4LYNNEK7NEK9NPM1NSD2PLK4+22

758 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.