Pregabalin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ESR1RATTUSMUSADRA1ACACNA2D1CACNA2D2
6 known targets mapped from PubChem bioassay data
Pathway Context
Neuronal System2 targets overlapping
Transmission across Chemical Synapses2 targets overlapping
Presynaptic depolarization and calcium channel opening2 targets overlapping
Uncovered Pathway Targets
139 totalABATABCC8ABCC9ACHEADCY9ALDH2ALDH5A1BCHECACNA1BCAMK1+129 more…
Genes present in the top pathway union that Pregabalin does not directly modulate.
Top Stack Candidates
Ondansetron
score 5,521.744#1 gap-filler · 19 targets covered · evidence score 56.7
ACHECHRNA4GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG2+7
gamma-Aminobutyric Acid
score 4,929.67#2 gap-filler · 19 targets covered · evidence score 43.1
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG2+7
485 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.