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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Progesterone

Progesterone — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRANFE2L2CHAINGLI3PGRRATTUSRORCNUCLEARTP53NR3C1ABCB1RARACHRM1HOMOESR2IFNGTSHRACHENR1H4ALDEHYDERXRAANDROGENABCB11GLUCOCORTICOIDSHBGNR5A1SIGMAR1SERPINA6GPBAR1MAPK1NR5A2CGMP-INHIBITEDESTROGENTARDBPSLC22A1SLC22A2NR3C2SIGMAFABP1SLC22A3HNF4ATRPC5NR4A2RORAAKR1C4ESRRGRARBADAM10NR1H2RARGSRD5A1SRD5A2CATIONCATSPER1CATSPER2CATSPER4DHCR24KCNJ1P2RX3HNF4GNR2F1

71 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway22 targets overlapping
SUMOylation15 targets overlapping
SUMO E3 ligases SUMOylate target proteins15 targets overlapping

Uncovered Pathway Targets

107 total
ESRRBNCOR1NCOR2NR0B1NR1D1NR1D2NR1H3NR1I3NR2C1NR2C2+97 more…

Genes present in the top pathway union that Progesterone does not directly modulate.

Top Stack Candidates

Quercetin

#1 gap-filler · 16 targets covered · evidence score 43.4

score 3,549.725
PPARGAURKBBLMNFKB2RELATOP1TOP2ACREB1HSP90AA1HSP90AB1HSPB1IGF1R+4
Daunorubicin

#2 gap-filler · 16 targets covered · evidence score 41.9

score 3,266.399
PPARDPPARGVDRBLMHDAC1HDAC2HDAC4HDAC7PARP1TOP1TOP2ACBFB+4

400 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.