Proguanil — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP1A2DRD1SLC6A2TAAR1PRKAA2PRKAA1PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3
11 known targets mapped from PubChem bioassay data
Pathway Context
Neuronal System7 targets overlapping
Transmission across Chemical Synapses7 targets overlapping
Regulation of T cell activation by CD28 family7 targets overlapping
Uncovered Pathway Targets
224 totalABATABCC8ABCC9ACHEADCY9ALDH2ALDH5A1BCHECACNA1BCACNA2D1+214 more…
Genes present in the top pathway union that Proguanil does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,672.736#1 gap-filler · 39 targets covered · evidence score 44.2
CREB1ADRM1EPAS1HIF1ANFE2L2NFKB1NFKB2PSMA1PSMA2PSMA3PSMA4PSMA5+27
Ondansetron
score 5,521.744#2 gap-filler · 19 targets covered · evidence score 56.7
ACHECHRNA4GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG2+7
636 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.