pyrrolnitrin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARNR1I2ESR1TDP1THRBCYP3A4TP53NR3C1USP28
9 known targets mapped from PubChem bioassay data
Pathway Context
SUMOylation5 targets overlapping
SUMO E3 ligases SUMOylate target proteins5 targets overlapping
Nuclear Receptor transcription pathway4 targets overlapping
Uncovered Pathway Targets
145 totalAURKAAURKBBIRC5BLMBRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2+135 more…
Genes present in the top pathway union that pyrrolnitrin does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,036.109#1 gap-filler · 47 targets covered · evidence score 44.2
HDAC1HDAC2MITFNFKB2PARP1PGRRARARELAESR2ESRRAPPARDADRM1+35
Luteolin 5,7,3',4'-tetrahydroxy-flavone,
score 5,091.716#2 gap-filler · 23 targets covered · evidence score 40.6
AURKBBLMNFKB2NR1H2NR1H3PARP1PPARGRELATOP1WRNCDK1CFTR+11
597 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.