BiohacksAI/Mechanism Hypothesis/rafoxanide

rafoxanide — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETHRBCYP3A4CYP3A7CHAINGLI3PGRRORCTP53ADRB2TSHRPMP22CFTRMDM2MDM4POLKHSPB1HTTBRCA1PPP1R15ABARD1RAPGEF3KAT2ARXFP1ANO1HCRTR1PIP4K2AHSPD1HSPE1ABHD17BSAE1UBA2SUMO-CONJUGATINGPNLIP

39 known targets mapped from PubChem bioassay data

Pathway Context

Deubiquitination10 targets overlapping

SUMOylation9 targets overlapping

SUMO E3 ligases SUMOylate target proteins7 targets overlapping

Uncovered Pathway Targets

180 total

ADRM1ARRB1BAP1CCNA1CDC25ACDK1EP300HIF1AIDEKAT2B+170 more…

Genes present in the top pathway union that rafoxanide does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 43 targets covered · evidence score 44.2

score 12,505.657

ADRM1HIF1ANLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+31

Quercetin

#2 gap-filler · 30 targets covered · evidence score 43.4

score 6,708.509

CDK1HIF1AOTUD3POLBPSMB5SMAD2SMAD3UCHL1USP10USP17L5USP28USP30+18

540 more candidates · full stack optimisation locked

Enter your API token to unlock the complete analysis.

BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.