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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Sirolimus

Sirolimus — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

NR1I2CYTOCHROMETDP1CHAINMUSABCB1DRD35-HYDROXYTRYPTAMINEADRA1AHOMODRD2HRH1ABCB11MAOAMTORSLCO1B1ABCG2PHOSPHATIDYLINOSITOLRAC-ALPHAPKMSLC29A1EIF4EPIK3CGPIK3R1PIK3CDPIK3CBPIK3CAAKT1FKBP1AMLST8PIK3R5PYRUVATERPTORPIK3R2FKBP4FKBP5PDCD4SMALLEUKARYOTICFKBP1BLARS1PEPTIDYL-PROLYLPIK3R3

43 known targets mapped from PubChem bioassay data

Pathway Context

Intracellular signaling by second messengers10 targets overlapping
PIP3 activates AKT signaling10 targets overlapping
PI3K/AKT Signaling in Cancer9 targets overlapping

Uncovered Pathway Targets

152 total
ADCY9ADRM1AGO2AKT3BADCAMK2BCAMK2DCAMKK1CAMKK2CASP9+142 more…

Genes present in the top pathway union that Sirolimus does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 45 targets covered · evidence score 44.2

score 12,732.983
ADRM1CREB1ESR1ESR2HDAC1HDAC2HDAC3PSMA1PSMA2PSMA3PSMA4PSMA5+33
Sorafenib

#2 gap-filler · 25 targets covered · evidence score 44.4

score 6,564.007
CAMK2BEZH2FGFR1FGFR2FGFR3FLT3FRKFYNGSK3BINSRIRAK1KIT+13

561 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.