BiohacksAI/Mechanism Hypothesis/Reserpine

Reserpine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7CHAINGLI3RORCNUCLEARTP53NR3C1ABCB1KCNH2EUCHROMATICCHRM1HOMOHTR2ACYP19A1AHRADRB2TSHRNTMT1ATAD5ACHEMU-TYPEGMNNABCB11CASP3TOP1P1BAZ2BCASP7GLSCBX1SCN2ACACNA1CTHPOMPHOSPH8SCN3ASCN1APSMB5SLC18A2BCHEABCB1AARFGAP1PSMB1PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMA8PSMB10PSMB11PSMB2PSMB3PSMB4PSMB6PSMB7PSMB8PSMB9KPNB1SNUPNRANSLC18A1

74 known targets mapped from PubChem bioassay data

Pathway Context

Transcriptional regulation by RUNX219 targets overlapping

Proteasome assembly19 targets overlapping

Deubiquitination18 targets overlapping

Uncovered Pathway Targets

170 total

ABL1ADRM1AKT3CBFBCCNB1CDK1CDK4CUL1GSK3BHDAC3+160 more…

Genes present in the top pathway union that Reserpine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 27 targets covered · evidence score 44.2

score 7,969.009

ADRM1HDAC3PSMC1PSMC2PSMC3PSMC4PSMC5PSMC6PSMD1PSMD11PSMD12PSMD13+15

Quercetin

#2 gap-filler · 33 targets covered · evidence score 43.4

score 7,436.589

ABL1CDK1GSK3BHDAC6SRCYES1HIF1AOTUD3POLBSMAD2SMAD3UCHL1+21

404 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.