BiohacksAI/Mechanism Hypothesis/Rimonabant

Rimonabant — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARCYP2C9TDP1THRBESRRACYP3A7SYKTYROSINE-PROTEINPGRRATTUSMUSNUCLEARKCNH25-HYDROXYTRYPTAMINEHOMOESR2PMP22MU-TYPEKAPPA-TYPEGMNNCHRM2ABCB11ADORA3ABCC2ALOX12CACNA1CCGMP-INHIBITEDABCC4RXFP1ABCC1HCRTR1ABCC3CNR1NR1I3FABP1GPR55CNR2CANNABINOID

38 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)7 targets overlapping

Drug ADME5 targets overlapping

Nuclear Receptor transcription pathway5 targets overlapping

Uncovered Pathway Targets

320 total

ADORA2BADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3+310 more…

Genes present in the top pathway union that Rimonabant does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 39 targets covered · evidence score 44.2

score 11,227.612

CYP2C19CYP3A4ESR1NR1I2PPARDRARACREB1ADRM1PSMA1PSMA2PSMA3PSMA4+27

Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on

#2 gap-filler · 38 targets covered · evidence score 44.3

score 10,373.468

ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3DRD2DRD3DRD4TSHRCYP2D6VDR+26

1056 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.