Rotenone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4NFE2L2SYKTYROSINE-PROTEINGLI3PGRNSD2RORCHISTONE-LYSINENUCLEARTP53ABCB1RARA5-HYDROXYTRYPTAMINEHTR2AESR2CYP19A1PPARGTSHRJUNNR1H4SMAD3GMNNRXRASMAD2ABCB11YAP1TOP1P1PPARDGLSCBX1MTORCDK1PRKAA2NPR2PRKAA1PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3CFL1NPR1ND4
54 known targets mapped from PubChem bioassay data
Pathway Context
Transcriptional Regulation by TP5312 targets overlapping
Regulation of T cell activation by CD28 family11 targets overlapping
Nuclear Receptor transcription pathway10 targets overlapping
Uncovered Pathway Targets
179 totalAGO2AKT3ATMAURKAAURKBBARD1BIRC5BLMBRCA1CARM1+169 more…
Genes present in the top pathway union that Rotenone does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,958.138#1 gap-filler · 40 targets covered · evidence score 44.2
HDAC1HDAC2ADRM1EPAS1HIF1ANFKB1NFKB2PSMA1PSMA2PSMA3PSMA4PSMA5+28
Quercetin
score 5,228.547#2 gap-filler · 23 targets covered · evidence score 43.4
AURKBBLMCSNK2A1CSNK2A2CSNK2BMAPK14NUAK1USP7YWHABEZH2GSK3BHIF1A+11
500 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.