Semustine 4-Methyl derivative of LOMUSTINE; (CCNU). — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
NR1I2ESR1ALDEHYDEALPHA-2ABRCA1ITGA4
6 known targets mapped from PubChem bioassay data
Pathway Context
SUMOylation3 targets overlapping
SUMO E3 ligases SUMOylate target proteins3 targets overlapping
Nuclear Receptor transcription pathway2 targets overlapping
Uncovered Pathway Targets
148 totalARAURKAAURKBBIRC5BLMCREBBPCTBP1DNMT1DNMT3BEIF2AK2+138 more…
Genes present in the top pathway union that Semustine 4-Methyl derivative of LOMUSTINE; (CCNU). does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,247.067#1 gap-filler · 49 targets covered · evidence score 44.2
ARHDAC1HDAC2MITFNFKB2PARP1PGRRARARELATP53ESR2ESRRA+37
Quercetin
score 5,317.555#2 gap-filler · 27 targets covered · evidence score 43.4
ARAURKBBLMNFKB2NR3C1PGRPPARGRELARXRATOP1TOP2ATP53+15
671 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.