Sertraline — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6CYTOCHROMECYP3A4SYKTYROSINE-PROTEINRATTUSNSD2MUSHISTONE-LYSINETP53ABCB1KCNH2CHRM15-HYDROXYTRYPTAMINEADRA1ADRD1HTR2BADRA2CJUNADRA2BATXN2SLC6A3SLC6A4MU-TYPESLC6A2HTR2CKAPPA-TYPESODIUM-DEPENDENTSTK33MDM2MDM4ALPHA-2AIFNB1IDH1ADRB1ALPHA-2BHLA-BALPHA-2CALPHA-1BMUSCARINICPPP1R15ACACNA1CSIGMAR1TAAR1APAF1CDK1KCNJ2TMEM97SIGMAMELANOCORTINNPR2SLC5A7SLC18A2MC3RVOLTAGE-GATEDUBE2NTRANSPORTERCFL1NPBWR1MCHR1
61 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)12 targets overlapping
Amine ligand-binding receptors9 targets overlapping
Hemostasis6 targets overlapping
Uncovered Pathway Targets
361 totalADORA2BADORA3ADRA1BADRA1DADRA2AADRB2ADRB3AGTR1AGTR2APLNR+351 more…
Genes present in the top pathway union that Sertraline does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,722.462#1 gap-filler · 37 targets covered · evidence score 44.2
F12HDAC1HDAC2PLATADRM1HDAC8PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6+25
Sorafenib
score 7,394.471#2 gap-filler · 30 targets covered · evidence score 44.4
ADORA3HTR6HTR7MLNRABL1CDK5CSKFGRFYNLCKLYNMAPK1+18
791 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.