Sorafenib — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
TDP1SYKTYROSINE-PROTEINCHAINNSD2RORCHISTONE-LYSINE5-HYDROXYTRYPTAMINEHOMOCYP19A1IFNGHTR2BSLC6A3PMP22HTR2CGMNNSTK33PTGS2IFNB1ABCB11ADORA3CA7HTR7HTR6MAOAHTR5AABCG2MAPK1ABL1GSK3BAURKBEPIDERMALCARBONICCDK1CLK1FLT3MITOGEN-ACTIVATEDCDK5MAPK14YES1SRCLCKCYCLIN-DEPENDENTSTK16MLNRKDRFYNRIPK2KITMETMAPK3BLKCSF1RPLK4DYRK3MACROPHAGEFOCALBCRSLKMAPK9PROTO-ONCOGENELYNRETMAP2K1AURKAMKNK2AXLMAPK11CYCLIN-A2MAP3K20MAP4K5MINK1CDK6INSRMKNK1BRAFEZH2EPHX2RECEPTORMAP3K7EPHB6FRKHIPK4IRAK1STK10FGFR1FLT4MAP4K4RPS6KB1JAK3TEKMAPK12VASCULARPDGFRBPLATELET-DERIVEDABL2FGFR3FGRFLT1NTRK1HIGHCAMK2BHCKMAP2K5CDK8MAPK13AURKCDDR1DDR2MAP3K19TNIKTTKEPHA3EPHB4LIMK1NTRK2TAOK1TGFBR2HIPK2RPS6KA1CITEPHA6RPS6KA6CDKL2CSKFGFR2MERTKRECEPTOR-INTERACTINGSRPK1TIE1TNK1EPHA2EPHA4EPHA8EPHB1EPHRINLIMK2NTRK3TNNI3KPDGFRARAF1CDK7MAPK15RAFRECEPTOR-TYPECDK19MYLK2MYLK3PTPN6EPHA1EPHA5EPHA7FPGT-TNNI3KMAP3K1MUSKNT-3TAOK2TAOK3EPHB2NLKSRMSSTK36CDK14CDK15CDK17CDK3HIPK1HIPK3ARAFCSNK1A1ANGIOPOIETIN-1CCNCCDKL3MAPMDH2MYO3BRETINALSTAT5A
178 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Receptor Tyrosine Kinases37 targets overlapping
Signaling by Interleukins23 targets overlapping
MAPK family signaling cascades23 targets overlapping
Uncovered Pathway Targets
231 totalADAM10ADAM17AKT3ALKAPH1AAPH1BATP6V1B2CDC37CDC42CDK5R1+221 more…
Genes present in the top pathway union that Sorafenib does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,922.48#1 gap-filler · 49 targets covered · evidence score 44.2
CMA1CREB1ESR1HDAC1HDAC2HDAC3HIF1AHSPB1PGRPLATADRM1CA1+37
Crizotinib
score 6,025.851#2 gap-filler · 19 targets covered · evidence score 46.7
ALKFERFESHPNIGF1RLTKMAPK7MST1RPTK2BROCK2TNK2IKBKB+7
692 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.