sp600125 — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6TDP1CYP1A2THRBESRRACYP3A4NFE2L2SYKTYROSINE-PROTEINCHAINNSD2HISTONE-LYSINETP53AHRIFNGALDEHYDEMDM2IL1BMDM4IFNB1HIF1AHDAC6POLBMAP4K2MAPK1GSK3BAURKBCDK1CLK1CSNK2A1GSK3AFLT3MITOGEN-ACTIVATEDPIM1DYRK1ACDK5PABPC1MAPK10LCKCYCLIN-DEPENDENTPIM2STK16KDRPROTEINKITMETBLKCSF1RPLK4DYRK3ROCK2FOCALSLKDUALMAPK9PROTO-ONCOGENELYNRETAURKAMKNK2CSNK1EDYRK2RPS6KA3GAKCYCLIN-A2MAP3K20MINK1ROCK1MAPK8INSRBRSK2CLK2CLK4TPTEP2-CSNK1EFRKHIPK4CDK2CHEK2FGFR1FLT4IKBKBMAP4K4RPS6KB1STK3JAK3TYK2MAPK12VASCULARFGFR3FLT1NTRK1HIGHLYSINE-SPECIFICMELKNAE1UBE2MCASEINMYLKPRKCGCAMK2BERBB4CSNK1DAAK1AURKCCDK16TNIKTTKEPHA3NTRK2TAOK1PIM3HIPK2MAP3K5CSNK1G1NEK2PHKG2CAMK2DCCNA1CDC7MARK2MARK3PDPK1KLK7BMP2KCAMKK2EIF2AK2STK4ULK3FESNTRK3PRKD2PRKD3DAPK3MAPK15RECEPTOR-TYPERPS6KA2SGK1STK17ABRSK1CSNK1G2FIBROBLASTFERTYRO3IRAK4ACTIVATEDRPS6KA5SGK2CHEK1CAMK2GCAMK1CAMK1GCSNK1A1CAMK1DCELLCSNK1G3DAPK2ERN1INHIBITORINSULINMATERNALMATKNEK4NON-RECEPTORPBKSTK38LTNFSF11
166 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Receptor Tyrosine Kinases30 targets overlapping
Intracellular signaling by second messengers23 targets overlapping
Cell Cycle22 targets overlapping
Uncovered Pathway Targets
315 totalADAM10ADAM17AKT3ALKAPH1AAPH1BATP6V1B2AXLBRAFCDC37+305 more…
Genes present in the top pathway union that sp600125 does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,998.35#1 gap-filler · 49 targets covered · evidence score 44.2
CMA1CREB1ESR1HDAC1HDAC2HDAC3HSPB1PGRPLATADRM1ESR2PSMA1+37
Quercetin
score 9,650.584#2 gap-filler · 43 targets covered · evidence score 43.4
ALKAXLBRAFCREB1ESR1HNRNPA1HSP90AA1HSPB1IGF1RMAPK14PGRPIK3R1+31
743 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.