Spermine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP1A2EUCHROMATICDRD1CASP3CA7CA4CA5ACA5BCA6CA14GRIN1GRIN2AGRIN2BGRIN2CGRIN2DKCNJ2GRIN3AGRIN3BTRPM7TRPM4KCNJ4CASRSAT1ODC1CASP2SMOXOAZ1TRPM5
29 known targets mapped from PubChem bioassay data
Pathway Context
Reversible hydration of carbon dioxide6 targets overlapping
Neuronal System5 targets overlapping
Transmission across Chemical Synapses5 targets overlapping
Uncovered Pathway Targets
205 totalCA1CA12CA13CA2CA3CA9ABATABCC8ABCC9ACHE+195 more…
Genes present in the top pathway union that Spermine does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,841.636#1 gap-filler · 40 targets covered · evidence score 44.2
CA1CA12CA13CA2CA3CA9CREB1ADRM1PSMA1PSMA2PSMA3PSMA4+28
Ondansetron
score 5,676.136#2 gap-filler · 20 targets covered · evidence score 56.7
ACHECHRNA4GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG2+8
598 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.