Sphingosine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
TDP1PPP1R15ATAAR1KCNQ1APAF1TNFRSF10BKCNQ2RAD52PROTEINUBE2NTRPM7GNA15HTRA1COPS5PRKCZPRKCAPRKCDPRKCGCCR6PRKCEPRKCQTRPM3PRKCBPRKCHSPHK1PRKACASPHK2
27 known targets mapped from PubChem bioassay data
Pathway Context
Hemostasis3 targets overlapping
Signaling by Receptor Tyrosine Kinases3 targets overlapping
G alpha (i) signalling events3 targets overlapping
Uncovered Pathway Targets
397 totalABCC4ABL1ADRA2AADRA2BADRA2CALBANXA2APPARRB1ATP1B1+387 more…
Genes present in the top pathway union that Sphingosine does not directly modulate.
Top Stack Candidates
Sorafenib
score 12,344.125#1 gap-filler · 48 targets covered · evidence score 44.4
ABL1CDK5CSKFGRFYNIFNB1LCKLYNMAPK1MAPK14MAPK3MERTK+36
Crizotinib
score 11,023.543#2 gap-filler · 41 targets covered · evidence score 46.7
ABL1ADRA2CCD74FGRFYNIFNB1LCKLYNMERTKSRCSYKTEK+29
888 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.