BiohacksAI/Mechanism Hypothesis/streptonigrin

streptonigrin — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

TDP1CHAINRORCMUSNUCLEARABCB1DRD3VDRTSHRATXN2ATAD5SLC6A3SMAD3MAPTMDM2IL1BMDM4IDH1POLKPOLBNFKB1APPPOLIUSP1GAPDHFEN1POLHSENP8BLMPDE4AAPAF1JAK2DDIT3APOBEC3GPTBP1L3MBTL1SENP6GRK2GLI1SENP7MPIATG4BARNTTACC3STAT1DLDGALK1KCNJ1SENP1PDE4CPADI4ATMUCHL5SENP2PADI2PADI3

56 known targets mapped from PubChem bioassay data

Pathway Context

DNA Repair8 targets overlapping

Signaling by Interleukins6 targets overlapping

Deubiquitination6 targets overlapping

Uncovered Pathway Targets

313 total

ABL1ALKBH5APEX1BAP1BARD1BRCA1CCNA1CDK2CDK7CHEK1+303 more…

Genes present in the top pathway union that streptonigrin does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 54 targets covered · evidence score 44.2

score 14,151.327

NSD2PARP1SEM1TP53ADRM1CA1CREB1CTSGHIF1AIFNGNFKB2PSMA1+42

Quercetin

#2 gap-filler · 52 targets covered · evidence score 43.4

score 10,669.484

ABL1NSD2SIRT6TP53USP10USP7ALOX15ALOX5CA1CREB1HIF1AHSP90AA1+40

877 more candidates · full stack optimisation locked

Enter your API token to unlock the complete analysis.

BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.