BiohacksAI/Mechanism Hypothesis/Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.

Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

TDP1NUCLEARABCB1IFNGTSHRATXN2CFTRSMAD3GMNNSTK33MDM2IL1BMDM4OPRM1IDH1HIF1AMITFYAP1OPRD1BRCA1PPP1R15ABARD1NR5A1PAX8NR5A2NCOA3GLP1RTNFRSF10BEPAS1MELANOCORTINNCOA1NR2F2GALR3NCOA2ATP1B1ATP1A4

36 known targets mapped from PubChem bioassay data

Pathway Context

Deubiquitination7 targets overlapping

SUMOylation6 targets overlapping

SUMO E3 ligases SUMOylate target proteins6 targets overlapping

Uncovered Pathway Targets

219 total

ADRB2ADRM1ARARRB1BAP1CCNA1CDC25ACDK1EP300ESR1+209 more…

Genes present in the top pathway union that Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 50 targets covered · evidence score 44.2

score 13,502.878

ADRM1ARESR1NLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+38

Quercetin

#2 gap-filler · 41 targets covered · evidence score 43.4

score 8,026.138

ARCDK1ESR1OTUD3POLBPSMB5SMAD2TP53UCHL1USP10USP17L5USP28+29

833 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.