Sulindac — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6CYP2C9NR1I2CYTOCHROMETDP1CYP1A2ESRRACYP3A4NFE2L2CHAINNUCLEAREUCHROMATICAHRRXRAPTGS2ABCC2AKR1B10AKR1B1GLRA1ALDO-KETOC5
22 known targets mapped from PubChem bioassay data
Pathway Context
Biological oxidations7 targets overlapping
Phase I - Functionalization of compounds7 targets overlapping
Cytochrome P450 - arranged by substrate type7 targets overlapping
Uncovered Pathway Targets
80 totalAADACAHCYALDH1A1ALDH2AOC1ARNTCBR3CES1CES2CYP11B1+70 more…
Genes present in the top pathway union that Sulindac does not directly modulate.
Top Stack Candidates
Ritonavir
score 2,761.057#1 gap-filler · 10 targets covered · evidence score 53.4
CYP2B6CYP3A43CYP3A5CYP3A7CYP3A7-CYP3A51PUGT1A1ABCB1SLCO1B1SLCO1B3SLCO2B1
Quercetin
score 2,697.294#2 gap-filler · 13 targets covered · evidence score 43.4
CYP19A1CYP1A1CYP1B1CYP2C8HSP90AB1MAOANNMTABCB1ABCC1ABCG2PON1SLCO2B1+1
538 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.