Suramin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
NR1I2CYP1A2CHAINRATTUSEUCHROMATICHTR1AVDRPOLKADORA3NNMTPNMTGAMTGNMTHNMTCATECHOLGLSUSP1IP6K1PRMT1PTPN1CGASPKMSIRT5GAMMA-AMINOBUTYRICP2RY11FHINOSITOLKMT2AP2RY6RYR1RYR2P2RY12P2RY2VASCULARDNA-DEPENDENTP2RX1P2RY1P2RY13ECTONUCLEOTIDEP2RX3PPM1DSIRT1P2RX2P2RX5SIRT2DUSP5NAD-DEPENDENTPKLRSIRT3
49 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)8 targets overlapping
Metabolism of amino acids and derivatives7 targets overlapping
Nucleotide-like (purinergic) receptors7 targets overlapping
Uncovered Pathway Targets
321 totalADORA2BADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3+311 more…
Genes present in the top pathway union that Suramin does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,886.339#1 gap-filler · 39 targets covered · evidence score 44.2
ADRM1PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4+27
Astemizole Antihistamine drug now withdrawn from
score 6,993.453#2 gap-filler · 34 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3+22
842 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.