BiohacksAI/Mechanism Hypothesis/triolimus [Supplementary Concept]

triolimus [Supplementary Concept] — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARNR1I2ESR1TDP1THRBSYKTYROSINE-PROTEINNSD2HISTONE-LYSINETP53NR3C1HOMOPMP22GMNNIFNB1HIF1AHLA-BHSP90AA1MTORABL1HSP90AB1HEATBCRRECEPTORLYSINE-SPECIFICKDM6BHSP90AA4PKDM4BKDM4CTRAP1

30 known targets mapped from PubChem bioassay data

Pathway Context

SARS-CoV Infections6 targets overlapping

Signaling by Rho GTPases, Miro GTPases and RHOBTB36 targets overlapping

Signaling by Rho GTPases6 targets overlapping

Uncovered Pathway Targets

292 total

AKT3ATP1A1ATP1A2ATP1A3ATP1A4ATP1B1ATP1B2ATP1B3BCL2L1BRD4+282 more…

Genes present in the top pathway union that triolimus [Supplementary Concept] does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 45 targets covered · evidence score 44.2

score 12,807.536

HDAC1HDAC2NFE2L2NFKB1NLRP3PSMC6RELASMAD3ADRM1HDAC8PSMA1PSMA2+33

Crizotinib

#2 gap-filler · 34 targets covered · evidence score 46.7

score 10,206.057

BTKIKBKBIKBKEIRAK1JAK3MAP3K7NPM1RIPK2ROCK2SRPK1TBK1TYK2+22

657 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.