Tolmetin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C9PTGS1PTGS2AKR1B1PROSTAGLANDINCXCL8ALDO-KETO
7 known targets mapped from PubChem bioassay data
Pathway Context
Fatty acid metabolism2 targets overlapping
Biosynthesis of DHA-derived SPMs2 targets overlapping
Biosynthesis of specialized proresolving mediators (SPMs)2 targets overlapping
Uncovered Pathway Targets
183 totalABCC1ACAD11AKR1C3ALOX12ALOX15ALOX15BALOX5CBR1CPT2CYP1A1+173 more…
Genes present in the top pathway union that Tolmetin does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,864.767#1 gap-filler · 47 targets covered · evidence score 44.2
CYP1A2CYP2C19PPARDCYP3A4ADRM1CA1CREB1CTSGHIF1AIFNGNFKB1NFKB2+35
Quercetin
score 6,531.375#2 gap-filler · 34 targets covered · evidence score 43.4
ABCC1ALOX12ALOX15ALOX15BALOX5CYP1A1CYP1A2CYP1B1CYP2C19CYP2C8HPGDPON1+22
863 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.