trametinib — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ABCB1MAPK1MAPK3DUALMAP2K1MAP2K2
6 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Receptor Tyrosine Kinases4 targets overlapping
MAPK family signaling cascades4 targets overlapping
MAPK1/MAPK3 signaling4 targets overlapping
Uncovered Pathway Targets
209 totalADAM10ADAM17AKT3ALKAPH1AAPH1BATP6V1B2AXLBRAFCDC37+199 more…
Genes present in the top pathway union that trametinib does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,494.538#1 gap-filler · 42 targets covered · evidence score 44.2
CMA1CREB1ESR1HDAC1HDAC2HDAC3HIF1AHSPB1PGRPLATADRM1PSMA1+30
Sorafenib
score 10,779.068#2 gap-filler · 40 targets covered · evidence score 44.4
AXLBRAFCDK5CSKFGFR1FGFR2FGFR3FLT1FLT3FLT4FYNINSR+28
551 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.