Trifluridine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
TDP1THRBESRRANFE2L2SYKTYROSINE-PROTEINGLI3NSD2HISTONE-LYSINENUCLEARTP53DRD3ESR2IFNGATXN2MDM2MDM4BRCA1NFKB1BARD1APPRELANCOA3JAK2NCOA1HOXA9TYMSMAP1LC3A
28 known targets mapped from PubChem bioassay data
Pathway Context
Cell Cycle8 targets overlapping
Signaling by Interleukins7 targets overlapping
Cell Cycle Checkpoints6 targets overlapping
Uncovered Pathway Targets
272 totalABL1ADRM1AKT3ATMAURKAAURKBBIRC5BLMCCNA1CCNB1+262 more…
Genes present in the top pathway union that Trifluridine does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,240.676#1 gap-filler · 48 targets covered · evidence score 44.2
ADRM1HDAC1HDAC8PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+36
Crizotinib
score 9,670.666#2 gap-filler · 33 targets covered · evidence score 46.7
ABL1AURKAAURKBCDK11ACDK11BEML4LYNNEK7NEK9NPM1PLK4SRC+21
790 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.