BiohacksAI/Mechanism Hypothesis/Tripterygium

Tripterygium — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARTDP1SYKTYROSINE-PROTEINCHAINNSD2RORCMUSHISTONE-LYSINENUCLEARTP53IFNGSTK33PTGS2IFNB1YAP1TOP1P1HLA-BHSF1JAK2MITOGEN-ACTIVATEDDDIT3NOD1KLF5F2RL1S1PR4S1PR3TRANSCRIPTIONCELLULARDCTPERCC3

31 known targets mapped from PubChem bioassay data

Pathway Context

Signaling by Interleukins6 targets overlapping

SARS-CoV Infections5 targets overlapping

Interferon Signaling5 targets overlapping

Uncovered Pathway Targets

447 total

ADRM1ALOX15ALOX5ANXA2APPBCL2L1BIRC5CA1CASP1CCL2+437 more…

Genes present in the top pathway union that Tripterygium does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 48 targets covered · evidence score 44.2

score 13,973.709

ADRM1CA1CREB1CTSGHIF1ANFKB1NFKB2PSMA1PSMA2PSMA3PSMA4PSMA5+36

Crizotinib

#2 gap-filler · 36 targets covered · evidence score 46.7

score 9,923.268

CSF1RFYNIKBKBINPPL1IRAK1IRAK3JAK3LCKLYNMAP2K3MAP3K3MAP3K7+24

961 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.