BiohacksAI/Mechanism Hypothesis/Valproic Acid

Valproic Acid — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2CYTOCHROMECYP1A2RATTUSMUSCHRM1DRD35-HYDROXYTRYPTAMINEADRA1ASLC6A3HRH1HDAC9CHRM3HDAC6HDAC10HDAC11HDAC4HDAC5HDAC7HDAC1HDAC2HDAC3HDAC8ABATALDH5A1

28 known targets mapped from PubChem bioassay data

Pathway Context

Signaling by NOTCH11 targets overlapping

Signaling by NOTCH111 targets overlapping

NOTCH1 Intracellular Domain Regulates Transcription11 targets overlapping

Uncovered Pathway Targets

70 total

ADAM10ADAM17ADRM1AGO2APH1AAPH1BARRB1ATP2A1ATP2A2ATP2A3+60 more…

Genes present in the top pathway union that Valproic Acid does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 37 targets covered · evidence score 44.2

score 11,301.033

ADRM1CREB1ELANEHIF1APSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+25

Reserpine

#2 gap-filler · 15 targets covered · evidence score 41.7

score 4,136.009

PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4PSMB5+3

289 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.