BiohacksAI/Mechanism Hypothesis/vinblastine sulfate

vinblastine sulfate — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6ARNR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3PGRNSD2RORCHISTONE-LYSINENUCLEARTP53ABCB1RARAESR2CYP19A1IFNGPPARGVDRJUNATXN2ATAD5CFTRNR1H4SMAD3MDM2MDM4SMAD2IDH1MITFHSPB1BRCA1BARD1NR5A1PAX8MCL1NR0B1NR5A2RELAHTR1EBCL2L1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TLR3RORAPLA2G3

67 known targets mapped from PubChem bioassay data

Pathway Context

Cell Cycle21 targets overlapping

SUMOylation16 targets overlapping

SUMO E3 ligases SUMOylate target proteins16 targets overlapping

Uncovered Pathway Targets

296 total

ABL1ADRM1AKT3ATMAURKAAURKBBIRC5BLMCCNA1CCNB1+286 more…

Genes present in the top pathway union that vinblastine sulfate does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 40 targets covered · evidence score 44.2

score 12,350.105

ADRM1HDAC1HDAC8PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+28

Crizotinib

#2 gap-filler · 36 targets covered · evidence score 46.7

score 10,474.636

ABL1AURKAAURKBCDK11ACDK11BEML4LYNNEK7NEK9NPM1PLK4SRC+24

639 more candidates · full stack optimisation locked

Enter your API token to unlock the complete analysis.

BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.