BiohacksAI/Mechanism Hypothesis/Vorinostat

Vorinostat — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ESR1TDP1THRBNFE2L2TP53NR3C1HOMOATAD5PMP22CFTRGMNNMDM2MDM4MITFHDAC9HDAC6PAX8NR0B1HDAC10HDAC11HDAC4HDAC5HDAC7HDAC1HDAC2HDAC3HDAC8GLI1PROTEINTUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8FXNACENCOR2HISTONEWNT3ANCOR1

50 known targets mapped from PubChem bioassay data

Pathway Context

Cell Cycle21 targets overlapping

Cell Cycle, Mitotic19 targets overlapping

Organelle biogenesis and maintenance18 targets overlapping

Uncovered Pathway Targets

243 total

ABL1ADRM1AKT3ATMAURKAAURKBBARD1BIRC5BLMBRCA1+233 more…

Genes present in the top pathway union that Vorinostat does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 39 targets covered · evidence score 44.2

score 11,683.071

ADRM1NSD2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3+27

Sorafenib

#2 gap-filler · 30 targets covered · evidence score 44.4

score 7,330.561

ABL1AURKAAURKBCDK1CDK6CDK7CSNK1A1GSK3BLYNMAPK1MAPK11MAPK14+18

667 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.